REPRODUCTIVE GENETICS

Reproductive  Genetics provides comprehensive reproductive genetic services to women and their families. The Division provides both preconception and prenatal assessment of genetic risk and counseling specially in couples who are interested or indicated to do PGD (Pre implantation genetic diagnosis):

24-Chromosome Pre-Implantation Genetic Screening (PGS)

Pre-Implantation Genetic Screening (PGS) allows for the screening of embryos during In Vitro Fertilisation (IVF) in order to identify abnormalities in the chromosomes caused by aneuploidy . Comprehensive Chromosomal Screening, screens all 24 chromosomes for aneuploidy, increasing your chances of achieving a healthy pregnancy and decreasing your risk of miscarriage by identifying embryos with the healthy number of chromosomes.

Is ExactCCS™ right for me?

  • Is PGS right for me?
  • How does PGS work?
  • What is Aneuploidy?
  • Where can I get testing?

Is PGS right for me?

Couples with a variety of medical histories have become pregnant following  IVF/PGS . Studies show that PGS may be most beneficial for couples meeting one of the following criteria:

  • Maternal age of 35 years or older
  • Repeated IVF failure
  • History of recurrent pregnancy loss

Couples have also chosen to complete 24-chromosome  CCS in the following circumstances:

  • Improve IVF success rate and reduce risk towards miscarriage: Aneuploidy is the leading cause of over 60% of IVF failures and pregnancy loss.
  • Male Factor Infertility: Male infertility factors, such as low quality sperm, have been linked with an increased rate of aneuploidy .
  • Concern for Down syndrome: In cases of a previous pregnancy involving aneuploidy or to reduce the risk of Down syndrome.
  • Interest in Gender Selection or concern for a sex-linked gender illness (if this service is offered by your healthcare provider).

Based on your medical history and personal preferenceOur Doctor in , Roya medical Center will consult with in order to determine if completing genetic testing such as PGS is right for you or not . For more information on PGS  to discuss any questions  related to genetic testing, or to learn about our IVF packaged contact Roya Medical Center ,Today !

Additional Information

Maternal age of 35 years or older:
As a woman ages, the quality of her eggs and her ovarian reserve diminish while the reproductive organs maintain their ability to carry a pregnancy. Several studies have shown that women of advanced maternal age are at an increased risk of producing aneuploid eggs and of spontaneous abortion, making maternal age of 35 years and older one of the most common indications for completing genetic testing such as PGS

Repeated IVF Failure:
Repeated IVF failure is defined as the absence of an ongoing pregnancy after 3 or more embryo transfers with high quality embryos. One of the leading contributing factor for repeated IVF failure is the development of aneuploid embryos. Studies show that at least 15% of couples with repeated IVF failure have an increased frequency of aneuploid embryos, a rate that substantially increases with maternal age.

History of Recurrent Pregnancy Loss:
In more than half of recurrent miscarriage cases, the diagnosis is unexplained infertility. Several scientific studies have verified that 80% of unexplained recurrent pregnancy loss in women over the age of 35 can be explained by aneuploid embryos. In every study completed using genetic screening services such as PGS, a decrease in the miscarriage rate was observed. Before choosing 24-chromosome PGS, couples that have had two or more miscarriages should consult with Dr. Roya Pourghorban  about having their own chromosomes tested to rule out inherited chromosomal rearrangements called translocations and inversions . For more information on Pre-Implantation Genetic Diagnosis testing for Inversions and Translocation, read about Inversion/Translocation PGD and 24-chromosome aneuploidy screening .

Genetic Carrier Screening
At the time of your appointment we will be asking you some questions about your family history and ethnic background. There are several genetic conditions that are more common in specific ethnic groups. The information below briefly reviews some general information about testing for these conditions. If you have questions about this information, please address them with the doctor during your scheduled appointment.

What are genes?
Genes are made up of a chemical called DNA and are the codes or instructions that tell the body how to grow and develop. These genes are arranged on strings of information called chromosomes. We have two copies of each chromosome, one that is inherited from our mother and one that is inherited from our father; as a result, we have one copy of each gene.

What are recessive diseases?
Many conditions are now known to be caused by changes, or mutations, in genes. Some genetic conditions, known as recessive conditions, are caused when a change or mutation is present on both genes of a pair. This means that both the mother and father must pass on the same changed gene in order for a child to have a recessive condition.

What is a carrier?
A carrier is a person who has a change in only one gene of a pair and the other gene of the pair is working normally. A carrier is sometimes said to have the disease trait but has no physical symptoms of the disease. In many families, a recessive gene change or trait can be passed on through generations without ever being known. A recessive disease can only occur if a person who is a carrier has a baby with another person who is also a carrier. Such a couple would have a 1 in 4 (25 percent)

chance, in each pregnancy, of having a baby with that recessive disease.

Who should be screened?
DNA tests are available to help a couple determine if they are carriers of the same recessive disease trait and are at risk for having children with that recessive condition. Some diseases occur more often in certain ethnic groups.  Information about the carrier frequency of the more common recessive disease traits in certain ethnic groups is provided below.  There are many other recessive conditions, not listed below, for which testing is not typically performed because the conditions are less common or because testing is not available.

ETHNICITY DISEASE CARRIER FREQUENCY
Ashkenazi Jewish: Tay-Sachs 1/30
Canavan 1/40
Cystic fibrosis 1/29
Familial Dysautonomia 1/30
Mediterranean: Thalassemia 1/20-1/50
Sickle cell anemia 1/30-1/50
European Caucasian: Cystic fibrosis 1/29
African American: Sickle cell anemia 1/10
Thalassemia 1/30-1/75
Cystic fibrosis 1/65
Asian: Thalassemia 1/20-1/50
Cystic fibrosis 1/90
Hispanic: Cystic fibrosis 1/46
French Canadian: Tay-Sachs 1/15
Cystic fibrosis 1/29


Is there prenatal testing?
If both parents are determined to be carriers of mutations for the same disease, a prenatal test is available to determine if the baby has that recessive disease.  In our affiliated  IVF centers in UAE preimplantation genetic diagnosis (PGD) is available to test an embryo for a genetic disorder before that embryo is transferred into the mother’s uterus.

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